Jun Yoshino, Joseph A. Baur, and Shin-ichiro Imai. NAD+ intermediates: The biology and therapeutic potential of NMN and NR. Cell Metab. 2018 March 06; 27(3): 513–528. doi:10.1016/j.cmet.2017.11.002.
This document provides a comprehensive exploration of the intricate relationship between nicotinamide adenine dinucleotide (NAD+) metabolism and aging.
It discusses the pivotal role of NAD+ intermediates like nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) in enhancing NAD+ biosynthesis and their potential health benefits.
The document also covers the impact of NAD+ decline on tissues like muscle, liver, and brain, as well as the effects of NMN and NR administration on various physiological outcomes in different mouse models.
Exciting preclinical results suggest that supplementing NAD+ intermediates could potentially improve human health and shed light on the therapeutic implications for age-related conditions and diseases.